Estimating the lipophilicity of a number of 2‐amino‐1‐cyclohexanol derivatives exhibiting anticonvulsant activity
Elżbieta Pękala, Henryk Marona · Biomedical Chromatography · 2009
The lipophilicity of a number of N-acyl derivatives of trans- or cis-: racemic, (1R,2R)- or (1S,2S)-aminocyclohexanol (1-13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (R(m0)) was determined using reversed-phase thin-layer chromatography (RP-TLC) with mixtures of methanol and water as mobile phases. The partition coefficients of compounds 1-13 (log P) were also calculated using two computer programs (Pallas and Chem DU) and compared with R(m0).