Robust segmentation of brain MRI using combination of registration and EM-based methods
Maria Deprez, Leigh E. Dyet, Joseph V. Hajnal, Mary Rutherford, A. David Edwards, Daniel Rueckert · 2007
Brain MRI segmentation is usually performed either based on intensity or non-rigid alignment with manually segmented image. Both of these approaches have drawbacks. Registration-based methods cannot often capture the complexity of cortical folding. On the other hand intensity-based methods assume homogeneous intensities of the tissues which is not well aligned with natural intensity variations of brain tissues. We combine both approaches to obtain a robust segmentation method which is successfully used on healthy and diseased brain MRI of 2-year-old children.