Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
Janet Sue Finer-Moore, R. M. Stroud · Proceedings of the National Academy of Sciences · 1984
Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.