Medicinal Chemistry: Challenges and Opportunities
Günther Wess, Matthias Urmann, Birgitt Sickenberger · Angewandte Chemie International Edition · 2001
The sequencing of the human genome has led to a wealth of new pharmaceutical targets. However, medicinal chemistry has proved to be a bottleneck in the search for active drugs. This bottleneck can be overcome by chemical biology, which is crucial in the transition from a trial-and-error mentality to a predictive approach.