Dependence of Molecular Properties on Proteomic Family for Marketed Oral Drugs
Michal Vieth, Jeffrey J. Sutherland · Journal of Medicinal Chemistry · 2006
An association of drugs with their proteomic family reveals that molecular properties of drugs targeting proteases, lipid and peptide G-protein-coupled receptors (GPCRs), and nuclear hormone receptors significantly exceed limits for some properties in the "rule of five", while drugs targeting cytochrome P450s, biogenic amine GPCRs, and transporters have significantly lower values for certain properties. Also, the variation in drug targets appears to be a factor explaining increasing molecular weight over time.