Oxygenation of biphenyl by the reagent system Fe(MeCN)62+-H2O2-Ac2O : An implication to the mechanism in mammalian metabolism.
Eiichi Kotani, Atsushi Midorikawa, Akira Tanaka, Seisho Tobinaga · Chemical and Pharmaceutical Bulletin · 1987
Oxygenation of biphenyl with Fe (MeCN) 2+6-H2O2-Ac2O, a model enzyme system for mono-oxygenase, was explored in connection with mammalian metabolism. The reaction yielded 2-and 4-acetoxy derivatives in a ratio of 2.5 : 1. The mechanism of this reaction may be a laboratory model explaining the biological mechanism whereby biphenyl is oxygenated by heme-containing mono-oxygenase.