Structure and Regulation of Type II Calcium/Calmodulin-dependent Protein Kinase in Central Nervous System Neurons
Mary B. Kennedy, Mark K. Bennett, Robert F. Bulleit, Ngozi Erondu, Vincent Jennings, Stephen G. Miller, Sean S. Molloy, Bruce L. Patton, L.J. Schenker · Cold Spring Harbor Symposia on Quantitative Biology · 1990
ed that molecular biology (the study of gene expres-sion) and neurobiology are at similar stages. Both fields have identified many of the cast of important charac-ters, but we still have much to learn about mechanisms and algorithms. In molecular neurobiology, the "mech-anisms " are the ways that individual proteins work together to regulate release of transmitter or to mod-ulate receptors and ion channels. The "algorithms " are the ways that these mechanisms are coordinated to allow neurons to maintain homeostasis, while at the same time adapting to changes in the external environ-ment and storing information through molecular changes that alter the behavior of neural networks. In the last several years, the field of molecular neuro-biology has appropriately placed great emphasis on