Pharmacological study on Norbormide
Mitsuaki NIU · Folia Pharmacologica Japonica · 1970
Norbormide, [5-(α-hydroxy-α-2 pyridylbenzyl)-7-(α-2 pyridylbenzylidene)-5-norbornene-2, 3-dicarboximide] is selectively toxic to the genus Rattus and its LD50 iss 5-10 mg/kg. It dose not produce significant changes in species other than the rat and its LD50 are more than 1 g/kg. Norbormide caused elevation of blood pressure in rats at the dose less than 1 mg/kg, while caused fall of blood pressure in dogs and rabbits at the dose of 10 mg/kg. The cause of death in rat by Norbormide are significat constriction and loss of tension of wall of peripheral blood vessels in organs.