Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors
Amir P. Tamiz, Miles P. Smith, Istvan J. Enyedy, J. Flippen-Anderson, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski · Bioorganic & Medicinal Chemistry Letters · 2000
The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule.