Rational design of small modified peptides as ACE inhibitors
Daniel Gedder Silva, Matheus P. Freitas, Elaine F. F. da Cunha, Teodorico C. Ramalho, Cleiton Antônio Nunes · MedChemComm · 2012
Computer-assisted techniques and the strategy of combining chemical substructures were used to derive small modified peptides as potent angiotensin-converting enzyme (ACE) inhibitors. In addition to high potency, some of the predicted compounds are also shown to exhibit satisfactory pharmacokinetic parameters.