Rapid Scale-Up of the Matrix Metalloproteinase Inhibitor CH5902: Process Safety and Route Development Considerations
Ian H. Smith, Anthony D. Alorati, Graham Frampton, Steve Jones, John O'Rourk, Martin Woods · Organic Process Research & Development · 2003
The synthesis of the novel MMP inhibitor CH5902 is described. In this approach, the original discovery route has been streamlined and telescoped into a four-stage sequence, which has been demonstrated on a multikilogram scale. A number of issues arising from both process development and process safety concerns are discussed.