In Pursuit of Higher Purity: Use of 13C NMR and 13C-Enriched Substrates To Trace Impurity Generation and Removal in the Synthesis of Atorvastatin
Robert A. Wade, Thomas M. Zennie, Christopher A. Briggs, Rex A. Jennings, Thomas N. Nanninga, Charles W. Palmer, Ronald J. Clay · Organic Process Research & Development · 1997
The use of 13 C-labeled starting materials and intermediates in the synthesis of the lipid regulator atorvastatin is described. 13 C NMR of the 13 C-enriched intermediates allowed monitoring of problematic nonchromophoric low-level impurities which were unobservable using standard analytical techniques.