Epigenetic modification of murine Cu,Zn‐superoxide dismutase
Futoshi Shibata, Zen-ichi Ogita · Electrophoresis · 1986
Abstract Murine Cu, Zn‐superoxide dismutase (SOD) from erythrocytes has three isozymes, SOD‐1A (pI 6.4), B (pI 5.7) and C (pI 5.0). It has been suggested that SOD‐1A is formed epigenetically by asymmetric modification of SOD‐1B where as SOD‐1C is produced by treatment of superoxide dismutase with hydrogen peroxide. On two‐dimensional gel electrophoretic analysis, each isozyme shows two forms, easily permuted into each other, and hence supposed to be in equilibrium. The zymogram patterns of murine liver, kidney, heart and brain are the same as those in erythrocytes although SOD activity levels are different in these tissues.