2n‐Factorial Schemes in Drug Design Extensions Increasing Versatility
V Austel · Quantitative Structure-Activity Relationships · 1983
Abstract Several extensions of 2n‐factorial series design are reported. These extensions comprise rotation of the factorial schemes as well as “axial” schemes. Thereby factorial series design becomes more flexible so that synthetic accessibility can be better accounted for. By combining 2n‐factorial schemes with axial schemes one can satisfy needs for larger numbers of samples which are required e.g. for deriving quantitative structure‐activity‐relationships or for deciding upon further examination of structural fields. The new schemes can be applied manually as well as in connection with pattern recognition techniques.