Exploratory data analytic techniques to evaluate anticancer agents screened in a cell culture panel
Louis Hodes, Kenneth D. Paull, Antonis D. Koutsoukos, Larry Rubinstein · Journal of Biopharmaceutical Statistics · 1992
Information theory is used to provide a measure of selectivity, i.e., the degree to which a drug has preferential toxicity or growth inhibition for one or a few cell lines from a large panel. The selectivity measure is intended to complement a measure of differential growth inhibition in evaluating the drug development potential of a new compound. Also, a similarity measure obtained from information theory is used to classify drugs according to their pattern of responses on the panel. Some structure-activity relations emerge. This work is applied to 176 agents selected to be tested by the National Cancer Institute in about 50 cell lines.