On the incompleteness of atomic models
Alexandre Urzhumtsev, Pavel V. Afonine, Vladimir Y. Lunin · Acta Crystallographica Section A Foundations of Crystallography · 2005
Structural models are auto-build and structures are refined, verified and analyzed using semi-automated computational tools.Functional analysis is being performed using a newly developed ProFunc server.3D models of relevant members of the sequence family are generated and their quality is assessed.Majority of the steps in the MCSG pipeline are tracked in near real time by the database.All the structures and their analysis are made available to the public using the MCSG database and web tools.The MCSG structure determination pipeline when combined with data collection facilities at third generation synchrotrons, advanced software and computing resources resulted in significant acceleration of structure determination of novel proteins.Using this pipeline the MCSG has determined 112 novel structures in 2004.