Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)
Shan‐Yen Chou, Wei‐Kung Yin, Yuh-Shan Chung, Lien‐Shange Chang, Chin‐Wei Liu, Shyh‐Fong Chen, Kae‐Shyang Shih · Organic Process Research & Development · 2002
This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.