A bayesian approach to bioassay. technical report m498
Richard M. Fagerstrom, Duane A. Meeter · Communications in Statistics - Simulation and Computation · 1983
We describe the design and analysis for a simulation experiment to compare the mean-squared errors (MSE's) of two quantile estimators defined for random walk designs. The dependence of the easily computed MSE of the first estimator on the levels of five factors is examined via multiple regression. This information is used to plan a simulation to compute the MSE of the second estimator using a fraction of a 3352factorial allowing uncorrelated estimates for all main effects and the two-factor interactions of a specified factor. Efficient estimation of the MSE of the second estimator is attempted through antithetic and control variate techniques of variance reduction, with modest success.