Studies on the Control of Hypertension by Hyphex
John D. Morrow, Henry A. Schroeder, H. Mitchell Perry · Circulation · 1953
Although effective in maintaining relatively normal levels of blood pressure in hypertensive patients and retarding some of the serious and fatal secondary consequences of the disease, hexamethonium ion and 1-hydrazinophthalazine can cause severe immediate and late reactions. The latter drug has produced collagen diseases of varying degrees of severity, all of which have regressed on cessation of medication, in 14 of 253 patients. The combination has given rise to fatal interstitial pneumonia in 5 of 89 in malignant stages of hypertension. Less serious side effects of each agent are also discussed.