Intracellular Receptors for Activated C-Kinase in the Postmortem Human Brain: No Alteration in Alzheimer Disease
Shun Shimohama, Shinji Kamiya, Takashi Taniguchi, Jun Kimura · Alzheimer Disease & Associated Disorders · 1998
Previous studies have identified a 36-kDa protein that has the properties of an intracellular receptor for the activated C-kinase (RACK1). In the present investigation we quantified levels of RACK1 protein in brains from patients with Alzheimer disease (AD) and age-matched controls. Western analysis using a specific antibody showed that the protein levels for RACK1 were not significantly different in AD brains than in controls, indicating that RACK1 is preserved in AD.