A comparative study of the lipophilicity of 1,2,4-triazoles by reversed-phase and micellar TLC and OPLC
Małgorzata Janicka, Katarzyna E. Stępnik, Anna Pachuta‐Stec · Journal of Planar Chromatography – Modern TLC · 2013
Lipophilicities of 21 newly synthesized 1,2,4-triazoles, compounds of potential importance as fungicides, have been determined by micellar and reversed-phase planar chromatography. Different stationary and mobile phases were used in the measurements. Chromatographic lipophilicities (log km and RM0) were correlated with partition coefficients log P (Alog Ps, AClog P, Alog P, Mlog P, KowWin, xlog P2 and xlog P3) calculated from molecular structures. Principal component analysis allowed a more objective comparison of different lipophilicity descriptors determined from various chromatographic systems and calculated theoretically as log P parameters.