In-Silico Identification of Potential Inhibitors Against AChE Using Cheminformatics Approach
Jitendra Kumar Gupta · MOJ Proteomics & Bioinformatics · 2014
Acetylcholinesterase (AChE) is highly viable target in Alzheimer’s disease (AD) as cholinergic deficit is consistent and early finding in AD. From previous studies, it has been proved that the Cholinesterase inhibitors (ChE-Is) are the only class of drugs approved by the Food and Drug Administration (FDA) for treatment of AD. Comparison of inhibitory activity of 15 different ChE-Is class of drugs was performed using cheminformatics and molecular docking approach against AChE. This approach helps to identify the binding affinity, mode of interaction and to understand the selectivity of drug molecule for the treatment of Alzheimer’s disease. This article suggests the best market available ChE-Is for AD.