RADICAL CURE OF RELAPSING VIVAX MALARIA WITH PENTAQUINE-QUININE: A CONTROLLED STUDY
Bernard Straus, Joseph Gennis · Annals of Internal Medicine · 1950
Article1 December 1950RADICAL CURE OF RELAPSING VIVAX MALARIA WITH PENTAQUINE-QUININE: A CONTROLLED STUDYBERNARD STRAUS, M.D., JOSEPH GENNIS, M.D.BERNARD STRAUS, M.D.Search for more papers by this author, JOSEPH GENNIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-6-1413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the recent war, extensive investigations were undertaken in the study and cure of malaria. These studies at first were directed particularly toward finding a substitute for quinine, the supply of which had been cut off by the enemy. It was soon found that quinacrine (atabrine), which had been known since 1930 but not sufficiently appreciated because of improper dosage, was a more satisfactory drug than quinine both as a suppressive and as a treatment of the acute malaria attack.1Quinacrine, however, has no effect on the relapse rate. Its toxic manifestations are not significant. In this country chloroquine, a...Bibliography1. MostHayman HJM: Relative efficiency of quinacrine (atabrine) and quinine in treatment of acute attacks of vivax malaria, Am. J. M. Sc. 211: 320-324, 1946. CrossrefMedlineGoogle Scholar2. LoebClarkCoatneyCoggeshallDieuaideDochezHakanssonMarshallManuelMcCoySaperoSebrellShannonCarden RFWMGRLTFRAREGEKCSORJJWHJAGA: Activity of a new antimalarial agent, chloroquine (SN 7618). Statement approved by the Board for Coordination of Malarial Studies, J. A. M. A. 130: 1069-1070, 1946. CrossrefMedlineGoogle Scholar3. 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AlvingCraigeJonesWhortonPullmanEichelberger ASBRCMTNL: Pentaquine (SN 13,276) a therapeutic agent effective in reducing the relapse rate in vivax malaria, J. Clin. Investigation (supplementary number, part 2) 27: 25-33 (May) 1948. CrossrefGoogle Scholar14. AlvingPullmanCraigeJonesWhortonEichelberger ASTNBRCML: The clinical trial of eighteen analogues of pamaquin (plasmochin) in vivax malaria, J. Clin. Investigation (supplementary number, part 2) 27: 34-45 (May) 1948. CrossrefGoogle Scholar15. Loeb RF: Activity of a new antimalarial agent, pentaquine (SN 13,276). Statement approved by the Board for the Coordination of Malarial Studies, J. A. M. A. 132: 321-323, 1946. CrossrefMedlineGoogle Scholar16. CraigeEichelbergerJonesAlvingPullmanWhorton BLRASTNCM: The toxicity of large doses of pentaquine (SN 13,276), a new antimalarial drug, J. Clin. Investigation (supplementary number, part 2) 27: 17-24 (May) 1948. CrossrefGoogle Scholar17. AtchleyYountHustedPullmanAlvingEichelberger JAEHJRTHASL: Reactions observed during treatments with pentaquine administered with quinacrine (atabrine), metachloridine (SN 11,437), and with sulfadiazine, J. Nat. Malaria Soc. 7: 118-124, 1948. MedlineGoogle Scholar18. Alving AS: Unpublished data. Google Scholar19. StrausGennis BJ: Evaluation of pentaquine as a cure of relapsing vivax malaria, Bull. New York Acad. Med. 24: 395-396, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 4, 1949.From the Medical Service, Veterans Administration Hospital, Bronx, N. Y.Published with permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or conclusions drawn by the authors.Helen Petrosene and Dr. Sydney Jampel provided material assistance in this study.Pentaquine was supplied through the courtesy of Dr. James A. Shannon, of E. R. Squibb and Sons. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and LaosThe use of primaquine for the treatment of malaria in Korean veterans 1 December 1950Volume 33, Issue 6Page: 1413-1422KeywordsChloroquineDrugsHospital medicineMalariaMedical servicesQuinineSurgery ePublished: 1 December 2008 Issue Published: 1 December 1950 PDF downloadLoading ...