Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters
Karl‐Heinz Baringhaus, Hans Peter Matter · 2007
10.1002/9783527619368.ch19.abs This chapter contains sections titled: Introduction The Origin of Lead Structures Optimization for Affinity and Selectivity Addressing Pharmacokinetic Problems ADME/AntitargetModels for Lead Optimization Integrated Approach Conclusions References