INTRANUCLEAR RODS IN PANCREATIC ISLET ß-CELLS
Lennart Boquist · The Journal of Cell Biology · 1969
In the course of ultrastructural studies on the morphology of the pancreatic islets of various rodent species used in current diabetes research, intranuclear rod-shaped structures were observed in the $-cells of mice .Since there appeared to be no previous reports on the occurrence of such structures in endocrine pancreas of any species, it was thought worth while to pay some further attention to them . MATERIALS AND METHODSThe animals were eight obese-hyperglycemic mice and 22 of their lean litter mates .They were originally obtained from the Jackson Laboratories, Bar Harbor, Maine, and subsequently bred at the Department of Histology and the Institute of Pathology, University of UmeA, Sweden.The mice were 4-16 mo old and of both sexes .They were kept on a standard laboratory diet and drinking water ad lib .