DESCRIPTORS FOR ARTEMISININ AND ITS DERIVATIVES; ESTIMATION OF PHYSICOCHEMICAL AND BIOCHEMICAL DATA
Michael H. Abraham, William E. Acree · University of North Texas Digital Library (University of North Texas) · 2013
Properties, or descriptors, of artemisinin and some of its derivatives have been obtained from known solubilities and water-octanol partition coefficients. These descriptors can then be combined with already known equations to yield water-solvent partition coefficients and solubilities in a very large number of solvents, so that it is now possible to select suitable solvents for purification, etc. Combination of the descriptors with known equations for blood-tissue partitions enables partition coefficients to be estimated for partitions from blood to brain, muscle, liver, lung, kidney, heart, skin and fat. Where data on blood-tissue partitions exist, there is agreement with experiment.