The Role of Target Binding Kinetics in Drug Discovery
Dong Ming Guo, Laura H. Heitman, Adriaan P. IJzerman · ChemMedChem · 2015
Traditionally structure-activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure-kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics-directed drug design and discovery is also proposed.