A systems approach to identification and validation of biomarkers
Gordon Brent Mills, UT M. D · Clinical Cancer Research · 2010
Abstract The realization of the promise of personalized molecular medicine will require the efficient development and implementation of novel targeted therapeutics. The goal will be to deliver the right drug to the right patient at the right time at the right dose. This effort will require an integration of information from the DNA, RNA, and protein level into predictors of which patients are likely to benefit from particular therapies. The overall likelihood of response to particular drugs represents the interaction between predictors of sensitivity with predictors of resistance. This session will use examples with predictors from the DNA, RNA, and protein level to illustrate some of the opportunities and challenges to the implementation of personalized medicine. It will demonstrate the need to integrate information from multiple technological platforms into visualizable pathways and networks as a key step in the process.