On a Distribution Function Arising in Computational Biology
Craig A. Tracy, Harold Widom · Birkhäuser Boston eBooks · 2002
Karlin and Altschul in their statistical analysis for multiple high-scoring segments in molecular sequences introduced a distribution function which gives the probability there are at least r distinct and consistently ordered segment pairs all with score at least x. For long sequences this distribution can be expressed in terms of the distribution of the length of the longest increasing subsequence in a random permutation. Within the past few years, this last quantity has been extensively studied in the mathematics literature. The purpose of this note is to summarize these new mathematical developments in a form suitable for use in computational biology.