Structural Determinants of Promiscuous and Specific Binding in Protein—Protein Complexes Using Component Analysis Techniques
Aiman Sherani · Wellesley College Digital RepositoryWellesley (Wellesley College) · 2015
Understanding the physical and chemical principles governing specificity and promiscuity in protein-protein binding is important both for understanding mechanisms of molecular recognition and for designing novel biomolecular systems.The goal of this project is to identify if the energetic contributions of structural moieties (e.g., side chains and backbones of individual residues) are different between promiscuous and specific protein-protein interactions.To achieve this goal, we are testing multiple hypotheses; for example, we hypothesize that specific proteins, which selectively bind to only one partner, preferentially utilize side chains to mediate binding when compared to