Local lung tissue expansion analysis based on inverse consistent image registration
Kunlin Cao · 2008
This thesis work describes a technique to estimate local lung \t\t\t\ttissue expansion using non-rigid inverse consistent image \t\t\t\tregistration on multiple respiratory-gated CT images of lung \t\t\t\tacquired at different inflation levels. The information of local \t\t\t\tlung tissue expansion is revealed by the Jacobian of \t\t\t\ttransformation, intensity-based specific volume change, and \t\t\t\tstrain resulted from the registration displacement field. \t\t\t\tComparisons between the registration-derived regional lung \t\t\t\texpansion estimates and xenon CT-derived regional ventilation \t\t\t\tmeasure on six sheep at supine position were made to validate \t\t\t\tthe estimates based on registration and find the suitable \t\t\t\tinflation level change to characterize the lung expansion using \t\t\t\tthis technique.