Potency Of 2-Phenylethyl Pentanoate to Increase The Activities of Inh, Sm, and Eta Antibiotics against Mycobacterium Tuberculosis Strain H37Rv
Firdaus Zenta, Ahyar Ahmad, Maria Claudia Vega · 2013
A research about potential of 2-phenylethyl pentanoate ester in order to be used in an effort to increase the activity of antibiotics INH, SM and ETA against M. tuberculosis strain H37Rv had been done. The 2-phenylethyl pentanoate ester was synthesized by Fischer esterification reaction of 2-phenylethanol and pentanoate acid in mole ratio 1:2, 2:1, 3:1 and 5:1. Characterization of ester as product was conducted using refractometer, FTIR and H-NMR. The product of the synthesis of 2-phenylethyl pentanoate obtained as colorless liquid. From this research was known that optimum mole ratio of 2-phenylethanol and pentanoate acid in Fischer esterification reaction to obtained 2-phenylethyl pentanoate was 5:1 in 39,59 % yield. The antibiotic activity essay of INH, SM, and ETA by 2-phenylethyl pentanoate against M. tuberculosis was done by measuring the MIC with 9 variations of antibiotic and ester concentration in MGIT medium. The 2-phenylethyl pentanoate could to increase antibiotic activity of SM and ETA. MIC value to SM 1 μg/mL in combination with 2-phenylethyl pentanoate 0.1 mM and value to ETA 0,5 μg/mL in combination with 2-phenylethyl pentanoate 1 mM.