THE STUDY OF THE LIPOPHILICITY OF NOVEL ANTIBACTERIAL ACTIVE PYRAZOLE DERIVATIVES CONTAINING A CARBOXAMIDE GROUP
Monika Pitucha, Joanna Matysiak, Beata Polak, Anna Pachuta‐Stec · Journal of Liquid Chromatography & Related Technologies · 2013
The retention behavior of biologically active pyrazoles has been determined using RP-18 TLC and IAM chromatography. The experimental parameters of lipophilicity of the studied compounds were determined and compared with calculated partition coefficients obtained by using of different algorithms. The results of lipophilicity-activity relationships and the selected mathematical models (MLR) indicate the important role of lipophilicity in the antibacterial activity of the group of the compounds under consideration.