Coding and Computing Join Forces
Bernard Chazelle · Science · 2007
process extension, and how is the megakaryocyte submembrane cytoskeleton disrupted to allow proplatelet protrusion? Does iron deficiency or inflammation change platelet size and number by affecting proplatelet formation? And because proplatelets issue only from large polyploid megakaryocytes, what are the mechanisms that uncouple megakaryocyte DNA replication and cell division, leading to polyploidy? The elegant intravital look at platelet formation provided by Junt and col-COMPUTER SCIENCE leagues has only increased our appetite to more fully understand thrombopoiesis, and in so doing, potentially intervene in the process for therapeutic benefit of patients who lack an adequate homeostatic defense.