Flexible Two-Stage Designs: An Overview
Werner Brannath, Martin Posch, P. Bauer · Methods of Information in Medicine · 2001
In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.