DESIGN, DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN NANODROPLETS
R. Sureshkumar · European Scientific Journal ESJ · 2014
Fibrate and statin combinational therapy is used to treat severe and refractory mixed hyperlipidemia. Hence lipid based SNEDDS were prepared using the concentration oil (2:1) and SCoS (1:1) which resulted in enhanced extent of absorption and relative bioavailability of 1.69 (fibrate) and 1.64 (statin). An approximately 40% of drug was available for systemic circulation via lymphatic route of absorption. The results showed a significant difference between the marketed and the SNEDDS