Scaling physiological pharmacokinetic models by physiological time
Richard C. Ward, Curtis C. Travis · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 1987
This paper shows that a multicompartment physiological pharmacokinetic model, used to account for inhalation exposure to volatile chlorohydrocarbons in mammalian species, can be made species-independent if chronological time is re-expressed in terms of physiological time. Physiological time is defined as chronological time divided by species body weight to the 1/4 power. We demonstrate the usefulness of this time scaling of the multicompartment physiological pharmacokinetic model by using it to model the inhalation of the volatile chlorinated hydrocarbon tetrachloroethylene in mice, rats, and humans. 8 refs., 2 figs.