Enhancing Hit Quality and Diversity within Assay Throughput Constraints
Iain J. McFadyen, Gary Walker, Juan Alvarez · Methods and principles in medicinal chemistry · 2005
This chapter contains sections titled: Introduction What Makes a Good Lead Molecule? Compound Collections – Suitability as Leads Compound Collections – Diversity Data Reliability Selection Methods Enhancing Quality and Diversity of Actives Methods Screening Library Determination of Activity Threshold Filtering High-Throughput Screen Clustering Algorithm (HTSCA) Diversity Analysis Data Visualization Results Peptide Hydrolase Protein Kinase Protein–Protein Interaction Discussion and Conclusion