Chapter 3: Auto-inhibition and - auto-intervention in one-state models
Niels Bindslev · 2008
This chapter is split into four divisions. The first division comprises formulations for the modeling of ligand-dependent auto-inhibition as well as for a so-called ‘low-dose hook-effect’; all related to simple auto-intervention in one-state models. The second division is a general introduction to biological auto-regulation and control, and also includes reflections on the meaning of ‘self’. Several separate issues relate to biological self-regulation. In the field of ligand-receptor interactions, auto-regulation may relate to either ligand-induced alteration of a receptive unit or to control induced within receptive units per se before further down-stream feedback regulations. The third division deals with concentration-dependent auto-inhibition and time-dependent phenomena, such as ligand-induced desensitization, both types eliciting auto-regulatory inhibition in receptive systems with only one type of ligand. The chapter also treats various aspects of desensitization including homologous and heterologous desensitization with examples of intrinsic (receptor-dependent) and extrinsic (phosphorylation-dependent) desensitization. The fourth division includes additional examples of models related to ligand-dependent auto-inhibition and desensitization. Citation: Bindslev N 2008. DOI: 10.3402/bindslev.2008.5