Simulations of Absorption, Metabolism, and Bioavailability
Michael B. Bolger, Robert Fraczkiewicz, Viera Lukáčová · Methods and principles in medicinal chemistry · 2008
This chapter contains sections titled: Introduction Background Use of Rule-Based Computational Alerts in Early Discovery Mechanistic Simulation (ACAT Models) in Early Discovery Mechanistic Simulation of Bioavailability (Drug Development) Regulatory Aspects of Modeling and Simulation (FDA Critical Path Initiative) Conclusions References