Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method
Dagmar Ringe, Carla Mattos · Methods and principles in medicinal chemistry · 2006
This chapter contains sections titled: Introduction Solvent Mapping Characterization of Protein–Ligand Binding Sites Functional Characterization of Proteins Experimental Methods for Locating the Binding Sites of Organic Probe Molecules Structures of Elastase in Nonaqueous Solvents Organic Solvent Binding Sites Other Solvent Mapping Experiments Binding of Water Molecules to the Surface of a Protein Internal Waters Surface Waters Conservation of Water Binding Sites General Properties of Solvent and Water Molecules on the Protein Computational Methods Conclusion Acknowledgments References