A Matrix Pencil Approach to the Blind Source Separation of Artifacts in 2D NMR Spectra
K. Stadlthanner, Elmar Wolfgang Lang, Wolfram Gronwald · University of Regensburg Publication Server (University of Regensburg) · 2003
Multidimensional proton nmr spectra of biomolecules dissolved in aqueous solutions are usually contaminated by an intense water artifact. We discuss the application of the generalized eigenvalue decomposition (GEVD) method using a matrix pencil to solve the blind source separation problem of removing the intense solvent peak and related artifacts. 2D NOESY spectra of simple solutes as well as dissolved proteins are studied.