On the toxicity of the aromatic diamines and their tetramethylcarboxylic acid derivatives
P. Gili, Alfredo Mederos Martín · Revista de la Sociedad Química de México · 2000
The use of the theoretical PALLAS 3.0 program, to study the toxic behaviour of tetramethylcarboxylic acids, potential pharma- ceuticals derived from o-phenylenediamines, indicates that o-pheny- lenediamines are highly toxic (level 1), while the tetramethycar- boxylic acid derivatives (o-PhDTA and 3,4-TDTA) are slightly toxic, similar to EDTA (level 3). Therefore these ligands o-PhDTA and 3,4- TDTA, similar to EDTA, can be used as sequestering agents of toxic metals and overload of essential metals in biological systems.