Chemogenomics Approaches to Ligand Design
Thomas Klabunde · Methods and principles in medicinal chemistry · 2006
This chapter contains sections titled: Introduction to Chemogenomics: Similar Receptors Bind Similar Ligands Focused Libraries and Screening Collections Directed Against GPCRs Physicochemical Property-based Selection of GPCR Screening Sets Pharmacophore and Molecular Descriptors for GPCR Directed Libraries Privileged-fragment-based GPCR-directed Libraries GPCR Collection and Subfamily-directed Library Design Understanding Molecular Recognition: Impact on GPCR Ligand Design Sites for Ligand Recognition within Biogenic-amine-binding and Other GPCRs Design of GPCR-directed Libraries Using “Motifs” and “Themes” “Chemoprints” for Recognition of GPCR-privileged Fragments Molecular Interaction Models by Proteochemometrics Outlook