Correlations between PAMPA Permeability and logP
Karl J. Box, John E. A. Comer, Farah T.T. Huque · 2007
It is useful in drug research and development to know whether and to what degree drugs are absorbed and transported in the human body. One way to find out is to measure drug absorption in vivo in humans, for it certainly tells people what they want to know– that the drug was absorbed. These measurements are made during the late-stage development of drugs that are likely to come to market. When investigating the properties of newly discovered drugs, it is also useful to assess whether they may be absorbed. However, in vivo experiments during the discovery process are out of the question for a number of reasons – not enough drug is available, the cost of experiments is very high, and the toxicity of the drug has not yet been assessed.