A Position Paper : On Synaptic Signaling with Frequency Neurons
Dan Lundh · 1996
This paper should be considered as a position paper of an on-going research project at the University of Skovde. This paper contains a neuron-frequency model, which is used to set-up a hypothetical regulatory network for molecular reactions in synaptic signaling. Experimental studies shows that the concentration of a protein called Synapsin I, together with the calcium inflow, regulates the amount of neurotransmitters released from the synaptic terminal (M. Kennedy in [5]). The aim here is to view the regulatory network, i.e synthesis of synapsin I, as part of the inter-cell communication. 1 Frequency Modelling A simplified model of the firing frequency 1 , under the assumption that the leakage is constant, the potassium channels regulate the refractory period and the sodium channel regulate the depolarization, could be stated as: f = ! r (Hz) (1) where the permeability ! (or rather the channel dynamics) could be expressed by a series of complex equations but for simplicity reaso...