Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D
Lutz Müller, Alexander Breidenbach, Christoph Funk, Wolfgang Muster, Axel Pähler · Computational Toxicology · 2006
This chapter contains sections titled: Attrition Causes Chemistry and Toxicity Targets and Toxicity Toxicology and ADME Assays and Their Expectations Expectations From “In silico” Models on Toxicity Prediction Safety Pharmacology Assays and Their Expectations Success/Failure Examples with Computational Approaches in The Drug Development Process Local versus Global SAR Models for Toxicity Prediction Shortcomings of Current Processes and Methods; Improvement in Education Regulatory Aspects References