Pathway Finding from Given Time-Courses Using Genetic Algorithm
Shinichi Kikuchi, Daisuke Tominaga, Masanori Arita, Masaru Tomita · Proceedings Genome Informatics Workshop/Genome informatics · 2001
We have developed an efficient algorithm based on the Genetic Algorithm (GA) for esitimating parameters of S-system [4]. The S-system belongs to power-law formalism, and is rich enough in structure to capture all relevant dynamics. For example, it is known that S-system can express genetic networks or metabolic pathways. In this work, we propose a method which can not only approximate time-courses but also find skeletal pathways. Our method is adopted by E-CELL project [5].