Structural Aspects of Kinases and Their Inhibitors
Rogier C. Buijsman · Methods and principles in medicinal chemistry · 2004
This chapter contains sections titled: Introduction Structural Aspects of Kinases The General Structure of an Activated Kinase Kinase Activation Kinase Inhibition Principles Substrate-competitive Inhibitors ATP-competitive Inhibitors Activation Inhibitors/Allosteric Modulators Irreversible Inhibitors Structural Aspects of Kinase Inhibitors Kinase Inhibitor Scaffolds Selectivity Issues The Selectivity Dogma The Gatekeeper Hinge-directed Selectivity Binding Region II-directed Selectivity Outlook