ANTI-INFLAMMATORY ACTIVITY OF HMG CO A REDUCTASE INHIBITORS: A COMPARATIVE STUDY
Rajitha Panonnummal, Joyamma Varkey · International Journal of Pharmacy and Pharmaceutical Sciences · 2015
Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac. Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method. Results: The results of our study revealed that atorvastatin and rosuvastatin showed effective in vitro (500mcg/ml) anti-inflammatory activity when compared with the standard drug diclofenac. Conclusion: The rosuvastatin was more potent anti-inflamatory drug when compared with atorvastatin.